Question about regimes

[UrbanBubblegum]

Hi there!

So I have had an endoscopy back in january which confirmed infection of H. Pylori. This was a confirmed by a «quick test». I was prescribed: Metronidazole, clarithromycin and Nexium.

Breath test was done 12 weeks after the cure which confirmed that I am still infected.

A new endoscopy was done in May with biopsy testing. Yesterday I got the results by phone; it is intermediate (?) resistant.

It is resistant to Clarithromycin, and in vitro (maybe) resistant to Metronidazole. It is sensitive to Levofloxacin, Tettacycline and Amoxcillin.

Since I have a possible, but not confirmed serious, allergy to penicillin the gastro doc wants me to try: Amoxcillin, Levofloxacin, pepto-bisol and Nexium for 10 days.

Is this a good cure? Also, I am allergic to tetracyclins, so yeah... i get red dots/rash after a few tabs. They are a bit itchy. But no other symptoms as far as I remember.

So the doc told me, if this doesn’t work they are out of options. Is this true? May desensitization to tectracycline be an option if this fails?

Plus, he also said if Amoxcillin didnt work b/c reaction I could do Metronidazole instead?

[Helico_expert]

Yes, you can try Nexium, Bismuth, Amoxicillin and levofloxacin.

You can also ask for double dose Nexium, eg. 40mg BID, to boost the cure rate.

Hopefully you wont have too much trouble with Amoxicillin.

If it fails, you still have Rifabutin and Furazolidone. So dont worry.

[UrbanBubblegum]

Thank you for a quick reply to my post.
The fact that you name two other antibiotics to try is really uplifting, thank you!

What does BID mean?

The regime I am about to start is this (dosage):

Amoxicillin (750 mg), three times a day
Levofloxacin (500 mg), two times a day
Pepto Bismol (262 mg), four times a day
Nexium (40 mg), two times a day

In addition I have bought probiotics (50 billion per capsules) as I was told probiotics would increase success rate?

[Helico_expert]

BID = twice a day.

probiotics are fine. since they are harmless, you can take it as you wish. Some people finds it helpful in terms of preventing antibiotic related diarrhea or complication (side effects). However, since there are so many brands of probiotics out there, what works for other people may not work on you. You will have to try a few to find the one best suit you.

by the way, your treatment plan looks good.

[UrbanBubblegum]

Thank you for taking your time to answer my questions and replying so fast. I really appreciate it!

Looking forward to Tuesday. Going to hospital to start my treatment. Fingers crossed!

By the way, you mentioned two other antibiotics, may I ask which country I can find these if I am unable to get them in my country? I might go abroad to get help. Thank you!

[Helico_expert]

Hi, i am not too sure. Perhaps you can try contact this company.

www.trimed.com.au

They do supply antibiotics

[UrbanBubblegum]

I am sorry, I forgot to ask:

The specialist and hospital said I should take Amox, Levo, Bismut and Nexium together in one dose in the morning and evening. Is this true/safe/normal?

I ask because in the first regime I was told to take nexium one hour before, and then take the abx with food after that.

[Helico_expert]

Most importantly is to have your drugs spread out as evenly as possible.
for those that are to be taken twice a day... try take it every 12 hrs.
As for those to be taken 3 times a day.. try take it every 8 hrs.
and so on.

it doesnt matter if it is before or after food.

[UrbanBubblegum]

So, I started treatment on tuesday. I’ve had the same recations as last time - headache, neusea, fatigue. Today (friday) I have had stomach cramps from lunchtime and it still presist. What do you make of this?

Still have six days left of my treatment. My regime is AS above, and I take the pills AS direktesendte by my gastro specialist:

8AM (Amox, Levo, Pepto and Nexium),
12PM (Pepto),
14 PM (Amox)
16 PM (Pepto)
8PM (Amox, Levo, Pepto and Nexium).

[ankiwo72]

Since I have a possible, but not confirmed serious, allergy to penicillin the gastro doc wants me to try: Amoxcillin, Levofloxacin, pepto-bisol and Nexium for 10 days.

Is this a good cure? Also, I am allergic to tetracyclins, so yeah... i get red dots/rash after a few tabs. They are a bit itchy. But no other symptoms as far as I remember.

So the doc told me, if this doesn’t work they are out of options. Is this true? May desensitization to tectracycline be an option if this fails?

Plus, he also said if Amoxcillin didnt work b/c reaction I could do Metronidazole instead?

As a patient with a serious allergy to ampicillin and amoxicillin (however not penicillin!), I would encourage you to find a good experienced immunologist specifically with experience testing drug allergies to confirm if you have a true allergy vs. a more common medication rash as a side effect, as you may be using less effective treatment regimens unnecessarily if not truly allergic. If you are in fact allergic to an antibiotic, you can go through drug desensitization whereby you would be able to take the medication and would have no reaction for as long as you are taking the medication consistently; however once you stop taking it you automatically become allergic/sensitized to it again. I went through this procedure twice in order to take regimens with amoxicillin in them. It is a last resort, but for peace of mind you should seriously think about getting confirmation of either true allergy or non-allergy, as it could save your life one day.