Helicobacter Forums

Hi Helico_expert!

I've posted here before about symptoms coming back 2 weeks after my initial treatment in late November, and unfortunately, I've just tested positive again today (with stool test). Looks like we didn't kill off the bacteria completely and it took a while to be visible in the test since I've only been prescribed with PPIs and H2 blockers from Jan - Feb after seeing the GP a couple times for stomach/intestine discomfort.

I went to see my GP today, and was prescribed the same antibiotics (different dosage). So I was wondering if this treatment is okay to take? The reason I am asking is that both here and other online sources recommend switching to a different class of antibiotics (other than Amoxycillin that's hard to become resistant to) after a failed treatment.

My first initial treatment was Amoxycillin 500mg TID, Erythromycin 250mg TID, Omeprazole 20mg BID, Cimetidine 200mg TID.

The second line treatment I was just prescribed was Amoxicillin 250mg + clavulanic acid 125mg QID, Erythromycin 500mg QID, Omeprazole 20mg BID, Cimetidine 200mg QID and Probiotic live lacto-bacillus complex BID.

Thanks in advance!

I dont think taking increasing erythromycin dose is going to help.
This is because the gene the antibiotic is targeting has changed. So it doesnt matter how high the dose, it wont work.
unlike metronidazole, it's being pumped out the cell to reduce toxicity.
some mutation can lead to more efficient "pumping".
So increase the dose can compete with the "pumping" and ultimately kill the cell.

So you should try a different class antibiotic, for example levofloxacin or rifabutin. perhaps include bismuth to boost cure rate.

I see, thank you so much for responding! I have just booked an appointment to see a specialist on Monday, and hopefully will get another treatment prescribed.

In the mean time, do you think it would be okay to start the medicine (I.e amoxycillin and erythromycin) prescribed by my GP? Last time I took the antibiotics I had an immediate relief on the bloating and pain. If it won't interfere with a new treatment that I maybe starting this Monday (hopefully), then I'd love to take some just to help me through this weekend and to stop the Hpylori from growing.

your symptoms were relieved from taking PPI.
you may start the PPI and ignore the antibiotics until a new prescription is given.
take PPI as long as you need to relief the symptoms.
but remember, to get rid of the root of the problem, you need to eradicate H. pylori.

It was the same predicament I was in. Increasing the dosage of erythromycin won't help, in my opinion doodle cricket This is due to a change in the gene that the antibiotic is intended to target. Thus, no matter how large the dosage, it will not be effective.

To lessen toxicity, it is pushed out of the cell, unlike metronidazole. A few mutations may result in "pumping" that is more effective. Raising the dose could therefore cause the cell to eventually die by competing with the "pumpgeometry dash lite." Take PPIs to alleviate your symptoms for as long as necessary. But keep in mind that you must get rid of H. pylori in order to address the underlying issue.

I advise incorporating probiotics into your daily routine,fnf as they can help restore the balance of good bacteria in your gut and alleviate some of the side effects of antibiotic treatment.