Helicobacter Forums

Hello.

What are eradication rates if H.Pylori is resistant to just one of two instead of two antibiotics in the regimen?

An example: Levofloxacin plus Metronidazole combination. If H.Pylori is suscetible to Levofloxacin and resistant to Metronidazole, would it be enough to eradicate the bug?

Thats interesting question. I guess given that people like myself fail despite trying different antibiotics we need both to work.

Question from me is what if multiple therapy treatments failed. What is the measure of last resort or do we just live with h pylori, and manage symptoms via PPI and antacid?

Interesting question.

I think the more relevant question is how likely is H. pylori become resistant to the antibiotic.
base on our experience, metronidazole, ciprofloxacin, rifabutin, and clarithromycin are very easily to become resistant to
tetracycline, amoxycillin, furazolidone, and bismuth are very difficult to become resistant to.

So base on the combination of the antibiotics, you can still get good cure rate if your HP is only resistant to one of the easy antibiotic.

Second question is also very interesting.
H. pylori can lead to chronic inflammation. While most of the symptoms are caused by the acid, taking PPI can solve the symptomatic problem. But the chronic inflammation can lead to more problematic damage in the future, including cancer. So we dont recommend to leave it.

we do have cases where the patient tried every possible combination of antibiotics treatment and yet not able to get rid of H. pylori. There is no guideline to how to cure them. We ourselves are experimenting. Some researchers are suggesting to wait for a year, and then repeat the treatment. The idea is that the resistant strain is less fit compare to the wild type. So eventually they will revert to sensitive variant again. And then you can try the treatment again.

Good question! Although H. Pylori resistance to one antibiotic in a two-drug treatment reduces the rate of eradication,Buckshot Roulette individual circumstances make it difficult to pinpoint the precise success rate.

H. pylori is often treated with a combination of two antibiotics and a proton pump inhibitor (PPI) to increase the effectiveness of eradication. Common antibiotics used include clarithromycin, amoxicillin, metronidazole, and tetracycline Geometry Dash Lite

your point about some antibiotics being harder to develop resistance to (like amoxicillin or bismuth) is really interesting Geometry Dash Lite and gives me a bit of hope. It's good to know that even if resistance to one drug develops, the combination can still potentially work.
I’ve been through two rounds of failed treatments myself, and was wondering if anyone here has tried the "wait-and-retry" strategy after a year? Any success stories with that approach?