Helicobacter Forums

I'm reading a paper entitled Diagnosis of Helicobacter pylori infection in patients with atrophic gastritis: comparison of histology, 13C-urea breath test, and serology and there's this bit in it:

Two of the seven men (29%) who had regression of the corpus
atrophy had spontaneous seroconversion to H. pylori-
negative status during the follow-up period

Note that the authors are comparing blood samples taken 1985-1989 and tissue samples from 1989-1991 to new samples taken 1996-1997 and none of the men had received eradication therapy in the interim.

Now, I don't know whether there are false negatives with the blood tests that could account for this, but has spontaneous eradication been documented?

It is possible to have "spontaneous eradication" of H. pylori.
I believe it can happen when someone has an acute inflammation during the infection.

In your case, can your blood test detect IgM? That is a sign of early infection and I think the "spontaneous eradication" would have happened during early infection.

Yes, spontaneous eradication of Helicobacter pylori has been documented in some cases, although it is relatively rare and not fully understoodslope ball game