HP and IBS
Posted: Wed Feb 13, 2013 4:12 am
I have read conflicting reports and studies about HP being a possible cause for IBS.
Can anyone weigh in on this topic?
Can anyone weigh in on this topic?
anyway... some patients develop IBS after h. pylori treatment. So, IBS is not solely H. pylori's fault.
I would like to quote the following (adapted from http://onlinelibrary.wiley.com/doi/10.1 ... 984.x/full)
The association of enterohepatic Helicobacter spp. (EHS) and IBD has been extensively studied over the years [1]. However, the pathogenesis of IBD is still poorly understood, and EHS cannot be confirmed as causative agents. Last year, a review paper by Mukhopadhya et al. [2] comprehensively discussed the associations between IBD and various species belonging to the Proteobacteria phylum, which includes EHS. The authors offered a newer and more in-depth perspective on the importance of the interaction of intestinal microbiota and host in the disease and suggested that EHS might exploit host defense by driving a proinflammatory change, leading to intestinal microbiota dysbiosis and ultimately the development of IBD [2].
Tankovic et al. [3] presented a case report on the detection of Helicobacter canis by PCR (99.7% nucleotide identity with the type strain of H. canis) in a patient with Crohn's disease, suggesting that this EHS may play a role in the disease. However, a study of biopsy specimens from 160 Chinese IBD patients, diagnosed on the basis of clinical endoscopical, histologic, and radiological findings, revealed no significant difference in the presence of Helicobacter spp. DNA between IBD patients and controls [4].