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欧洲幽门螺杆菌治疗共识 5

C14 UBT and opinions needed

Breath tests are the most accurate way of detecting H.pylori without actually having an endoscopy (stomach examination). Breath tests are especially useful after treatment to make sure H.pylori is cured. Urea breath tests are known to be completely harmless. Either C14-urea or C13-urea tests are used. Read about them at the diagnosis section at where a diagram can be found. C14-urea breath tests use a radioactive tracer but such a tiny amount that it can be used safely at any age. It is a 15 minute test, convenient and inexpensive. The C13-urea test uses a stable isotope of carbon which is also harmless but requires two breath samples and takes about 30 minutes. Both tests have accuracy greater than 90%.

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Posts: 11
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Re: C14 UBT and opinions needed

Post by Ice006 »

Helico_expert wrote:
Tue Apr 19, 2022 2:26 pm

If you are over 50 year old, then you should get an endoscopy done, as a baseline reference. In case you need another endoscopy done when you are 60 or 70, then you have something to compare to and see how much worse it have become.
if you are young, around 30-50, mild symptom, then endoscopy is optional. However, if the doctor suspect that you have an ulcer, or have family history of gastric cancer, then endoscopy is still recommended.
I'm in this age range.
if you decided to take antibiotics and PPI, then you'll need to wait for at least 4 weeks before you go ahead for endoscopy.

these are the scenarios

Scenario 1.
you have HP and the treatment works.
your endoscopy would see some gastritis. histology will show inflammation retreating. no HP will be since when special stain is used.

Scenario 2.
you have HP and the treatment failed.
your endoscopy would see some gastritis. histology will show active inflammation. HP can be since when special stain is used.

Scenario 3.
You dont have HP. with or without treatment is the same.
your endoscopy may see gastritis. histology may see a bit of inflammation. no HP will be since when special stain is used.
"HP can be since when special stain is used" What does this mean? I don't understand the wording.

So basically, looking at what you're saying, if I'm understand correctly, it's going to change the histology if I take the antibiotics even if I get an endoscopy done 4-8 weeks after taking them?

Also, for scenario 3, is that if I don't take the antibiotics and don't have HP, or is that scenario if I take the antibiotics, but don't have HP?
Thanks a lot for replying. Really appreciate all the awesome help you've given me so far.

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Re: C14 UBT and opinions needed

Post by Helico_expert »

sorry for the typo... i meant to say even with special HP specific stains, the pathologist will not see HP.

if you have taken antibiotics 4-8 weeks ago, then if the treatment works, your gastritis will gradually recover, which can be revealed by histology.

if the treatment failed, then the gastritis will continue, which can also be revealed by the histology.

Scenario three is without HP. the antibiotics will not change the outcome of histology.

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