false negative biopsy result because of one nexium ???

[jonur]

Hi everyone,

I recently had an endoscopy done but I wasn't told that I shouldn't take Nexium or anything beforehand! I never took it long term, just once every couple weeks if I was heaving heartburn.

So three days before my endoscopy I took one 40mg nexium because I was having heartburn, and then 3 days later I had biopsy done to check for h. pylori and it came back negative. I forgot to tell my doctor that I took one nexium caplet 3 days before-do you think this could have produced a false negative? I've also been on probiotics for 2 weeks while this test took place too. Is this something I should bring up with GI doctor to see if she wants to retest???

I ended up being diagnosed with mild chronic gastritis and a small ulcer in my small intestine, which my GI said could be from me using Advil quite a few times over the last couple months.

[Helico_expert]

what about histology? by looking at the number of lymphocytes, the pathologist can tell if there is H. pylori. At least the endoscopy did not show you having any other severe abnormality.

alternatively, you can wait for a few more weeks, then do a breath test. That's very accurate too.

[jessica101]

It’s understandable to be concerned about the timing of your Nexium intake and the negative biopsy result for H. pylori. While Nexium (esomeprazole) can affect stomach acidity, leading some experts to suggest it might influence test results, the impact of a single dose taken three days prior is generally considered minimal. Probiotics can also play a role in gut health, but they typically don’t interfere with H. pylori tests.
contexto
It’s definitely a good idea to bring this up with your GI doctor. They can provide more personalized guidance and determine if retesting is necessary based on your specific situation and symptoms. It's always best to keep your healthcare provider informed about any medications or supplements you've taken, especially when undergoing diagnostic tests.

[Helengrace22]

I forgot to tell my doctor that I took one nexium caplet 3 days before.

Honestly, I’d definitely mention that to your GI just for peace of mind. Even one PPI dose can affect certain tests for some people, so it’s worth clarifying. It doesn’t mean your result is wrongCowboy Safari, but giving your doctor the full picture will help them decide whether retesting is needed.

[xaviernes]

As Jessica mentioned, it’s important to discuss these details with your GI doctor, as they can guide you on whether further testing is necessary. It’s always best to inform your healthcare provider of any medications or supplements you’ve taken before diagnostic tests to ensure the most accurate results.