PPI use and worse COVID-19 outcome, but H pylori and COVID says otherwise?
Posted: Sun Oct 25, 2020 9:17 am
So I just saw these three sources saying those who take PPIs longer than 6 months have worse outcomes of COVID-19 than those with smaller doses.
I'm taking omeprazole 20mg twice daily to control my H pylori infection because it's resistant to every antibiotic. I cannot go off my PPI or it'll get gastritis and a bleeding ulcer, like many times before. Can I go back to 20 mg once daily? I really feel these studies are too new to take it seriously, yet I do not want to take the risk. There is no way I can just go off it, or my chances of dying from an ulcer/gastritis will be much higher than dying from COVID. What should I do? Are these studies reputable?
I wear a mask, social distance and hand sanitize and so far have not gotten COVID and don't plan to.
but these studies freak me out. However, another study says H pylori can reduce a severe covid case: (These data support the rationale to suppose that gastric H. pylori colonization affects immune homeostasis and may play a role in damping the hyperinflammation characteristic of severe COVID-19 cases [14])
Bottom line: Three sources say, PPI use increase risk of COVID 19, one source says H pylori reduces severe risk. And another says O+ blood (I have) reduces risk. So which is it? I exercise daily, eat healthy, at a healthy weight, and take COVID rules seriously.
H pylori source:
https://www.bmj.com/content/368/bmj.m1198/rr-4
PPI and COVID source
https://www.gastroenterologyadvisor.com ... ronavirus/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7417108/
https://gut.bmj.com/content/early/2020/ ... 020-322248
I'm taking omeprazole 20mg twice daily to control my H pylori infection because it's resistant to every antibiotic. I cannot go off my PPI or it'll get gastritis and a bleeding ulcer, like many times before. Can I go back to 20 mg once daily? I really feel these studies are too new to take it seriously, yet I do not want to take the risk. There is no way I can just go off it, or my chances of dying from an ulcer/gastritis will be much higher than dying from COVID. What should I do? Are these studies reputable?
I wear a mask, social distance and hand sanitize and so far have not gotten COVID and don't plan to.
but these studies freak me out. However, another study says H pylori can reduce a severe covid case: (These data support the rationale to suppose that gastric H. pylori colonization affects immune homeostasis and may play a role in damping the hyperinflammation characteristic of severe COVID-19 cases [14])
Bottom line: Three sources say, PPI use increase risk of COVID 19, one source says H pylori reduces severe risk. And another says O+ blood (I have) reduces risk. So which is it? I exercise daily, eat healthy, at a healthy weight, and take COVID rules seriously.
H pylori source:
https://www.bmj.com/content/368/bmj.m1198/rr-4
PPI and COVID source
https://www.gastroenterologyadvisor.com ... ronavirus/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7417108/
https://gut.bmj.com/content/early/2020/ ... 020-322248
These are tricky questions and I cannot explain why the proton pump inhibitor would increase the risk of a severe outcome from COVID. Perhaps the virus is able to infect the gut rather heavily if the acid blockade is present.