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Management of Helicobacter pylori infection—the Maastricht V/Florence Consensus Report
The 5th Chinese Helicobacter treatment consensus
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欧洲幽门螺杆菌治疗共识 5
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H.pylori is a real BEAST

The cure of Hp usually requires antibiotics. Other things have been tried and have a weaker effect.

Moderator: barjammar

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H.P porteur
Posts: 32
Joined: Fri Nov 05, 2010 6:46 am

H.pylori is a real BEAST

Post by H.P porteur »

I was reading an interesting paper of a case study in one patient where they have tried 7 different types of antibiotics in cocktails to eradicate H.pylori with PPI but they all failed. The beast always grew back and caused the symptoms. The urease test was always positive.

What was interesting. The patient was put on monotherapy with Bismuth but for a long period ( over 6 months). Slowly, it started to improve in her symptoms on this suppressive therapy but the dragon was only sleeping, it was not slain.

I think Vonoprazan ( Potassium Proton inhibitor), Amoxicillin and Bismuth can slay the dragon if taken for a longtime. like 2 or 3 months instead for few days.

What you think?

Is there new game changer or new arsenal that can be added to achieve a much better eradication rate?

I read a study where injection IL2 ( interleukin 2) cured H.pylori and achieve 100% eradication rate. What you think of that?

I think we are close to 100% eradication rate of H.pylori if we keep playing with Bismuth, Potassium proton pump inhibitors like vonoprazan and Amoxocillin and liposomal formulations of other drugs plus some selective probiotics that are proved to reduce or suppress H.pylori load.

I think also that persister cells of H.pylori are to blame. Persisters were not known. They are almost immune to antibiotics. They wait until antibiotics are eliminated then they regrow the bacteria back. They are famous with TB, Lyme, chlamydia and other bacteria. I think H.pylori being a successful parasite can use persisters to survive. So Persister busters can get rid of it.

Also if we disable its acid protection, this can also lead to game over. This bacteria survives only because she knows how to desarm our HCL in the stomach. So research that can find a way to disable its protection mechanism toward HCL will lead to its eradication.

What you think?

Helico_expert
Site Admin
Posts: 4466
Joined: Wed Mar 02, 2011 7:20 am

Re: H.pylori is a real BEAST

Post by Helico_expert »

you are very up to date!

yes, vonoprazan is a game changer. We noticed that acid suppression is very important during antibiotic treatment. Vonoprazan is more superior than the convention PPI. Therefore, amoxicillin + vonoprazan is enough to achieve over 90% cure rate. It would probably be even stronger with addition of bismuth compound.

IL2 is an inflammation "inducer". Some studies have shown that acute inflammation can sometimes eradicate H. pylori. However, I dont think that's a good idea inducing inflammation in the gastric. You may end up having stomach ulcer or other problems in other organs.

H.P porteur
Posts: 32
Joined: Fri Nov 05, 2010 6:46 am

Re: H.pylori is a real BEAST

Post by H.P porteur »

Hi Helico-expert,

Yes I think in few years H.pylori will be easily treatable. With AI and other technologies like CRISPR, Potassium pump inhibitors like Vanoprazan.

I am confused with Amoxicillin is effective despite H.pylori is a gram negative. And why it cannot gain resistance to it?

This is an interesting booklet about a method achieving 100% eradication rate. It talks about biofilm, bismuth and other things.

https://www.amazon.com/100-eradication- ... 387&sr=8-3

H.P porteur
Posts: 32
Joined: Fri Nov 05, 2010 6:46 am

Re: H.pylori is a real BEAST

Post by H.P porteur »

Another question

Is it possible for H.pylori to cause chronic sinus infections or jaw infection or it is a rare phenomenon?

Some studies speak of a link between Sinus infections , gum infections, jaw infections and H.pylori. Maybe there are other reservoirs than the stomach?

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