Only registered users are allowed to post. To register, please click here

Should you have any problem in posting, registering, or login, please do not hesitate to contact the admin at Marshall.centre(at)gmail(dot)com. In the subject, please use "Help needed for"

Advertisement is not allowed. While we encourage discussion, please try not to promote your website, goods, or unproven treatment here.

This is a non-profit website. We will try our best to help anyone that has question about H. pylori and their treatment. We shall provide the most accurate answer about H. pylori. You can help us by clicking here to keep this forum alive.

Some useful guides
How to post in the forum?
Management of Helicobacter pylori infection—the Maastricht V/Florence Consensus Report
The 5th Chinese Helicobacter treatment consensus
How long should I wait before doing follow up breath/stool test?

If you are confirmed with H. pylori, in your convenient time, please help us with the symptoms survey that you are experiencing.
Symptoms survey
(contributed by frostyfeet)

若有困难注册,请联络站长 Marshall.centre(at)gmail(dot)com。标题请用 "Help needed for"

欧洲幽门螺杆菌治疗共识 5

Is there any research Re: H.pylori and late onset Midgut NETS?

The various unpleasant manifestations of Helicobacter can be described here. Remember however that the great majority of persons with Hp have no symptoms that they are aware of and consider themselves normal.

Moderator: barjammar

Post Reply
Posts: 1
Joined: Sun Feb 13, 2022 8:40 pm

Is there any research Re: H.pylori and late onset Midgut NETS?

Post by KMc »

Previous history of H.pylori 1988.
Present history of Midgut NETS 2020.
Question Re: Helicobacter pylori (H. pylori).

If this infection can sit in the stomach and the first part of the duodenum undetected for many years, with the serious consequence of cancer at the initial sites of infection, why can we not attribute the same bacterial infection to late onset Neuroendocrine tumours of the mid gut, the jejunum?

. Could H. pylori not be the rascal that triggers NETS later on in life?

. Have researchers looked at the NETS under the microscope to see if the H.pylori is present in these glands?

. Could NETS be caused by a viral infection which lies dormant as with H. pylori?

User avatar
Site Admin
Posts: 149
Joined: Fri Feb 05, 2010 11:10 am
Location: Perth Australia

Re: Is there any research Re: H.pylori and late onset Midgut NETS?

Post by barjammar »

OK, Neuro Endocrine Tumours of the G.I. tract are the issue here. Some genetic causes are known (MEN etc.) but usually the actual cause is not exactly known. They tend to be low grade malignancy so can be removed (if only one) but hard to cure if they spread. I have seen only a couple of cases in my life. I saw that an association with peptic ulcer has been reported but it's a "chicken or egg" question.
Certainly H.pylori triggers stem cells to migrate into the gastric mucosa, and stem cells can then be subjected to carcinogens in the diet, also to inflammation (free radicals), so there is a possible mechanism whereby NETS could be triggered from a stem cell mutation. So it may be a very rare effect of a common (H.pylori) disease.
So my recommendation is to search for Helicobacter and get rid of it. This means serology falling and urea breath tests and/or biopsies being negative.
As for MIDGUT NETS, the same thing applies but you know that H.pylori is hardly ever in that location so less likely a cause.
As for a viral cause? Certainly. I think slow or hibernating viruses are a possibility. With all these things you need to know exactly what you are looking for (so you have a DNA/PCR probe) otherwise you won't find it.
My life plan is (starting now) to continually survey children for viruses from cradle (now) to grave (100 years later) and see what viral sequences turn up. At least save a bank of samples, and some people in the world are already doing this. These can be probed retrospectively later if a person gets a rare disease like NETS. Who knows what will turn up.
There are two causes of disease: 1=Congenital/genetic 2=Environmental/infectious/toxicities
Seems simple but technology will solve.
Check the link below for information on hard-to-treat cases. Then search the forums for questions and answers similar to yours.

Donald Mitchell
Posts: 5
Joined: Tue Feb 02, 2021 3:20 am

Re: Is there any research Re: H.pylori and late onset Midgut NETS?

Post by Donald Mitchell »

Thanks a lot for the explanation. Juie has useful research findings that can help me in writing my texts at university. I have now turned for help to the service which helps me with writing articles, essays and written assignments.

Post Reply

Return to “Diseases and Symptoms 疾病与症状”